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Image Search Results
Journal: Frontiers in Neural Circuits
Article Title: Long-term Potentiation at Temporoammonic Path-CA1 Synapses in Freely Moving Rats
doi: 10.3389/fncir.2016.00002
Figure Lengend Snippet: mTAP-CA1 synapses and putative population spikes exhibit an enduring form of long-term potentiation (LTP) in freely moving rats. (A) Daily mTAP-CA1 (•, n = 6) and cCA3-CA1 (°, n = 6) slope analysis. Inset: baseline (solid line) and post-TBS (dashed line) mTAP-CA1 responses. Calibration: 0.5 mV, 5 ms. Three out of six animals exhibited heterosynaptic long-term depression following TBS of the medial TAP. (B) Curve fitting of post LTP daily slope averages indicate mTAP-CA1 LTP decay ( n = 6) is represented as a sum of two exponential curves with time constants (τ) of 2.7 days and 148 days to decay 63.2% of maximal LTP. (C) Daily mTAP-CA1 putative population spike amplitude analysis in animals that exhibited population spike potentiation following TBS ( n = 4). Significant differences between post- and pre-tetanus putative population spike amplitudes persist for 5 days after LTP induction [* p < 0.05, repeated measures one way ANOVA]. Inset: baseline (solid line) and post-TBS (dashed line) mTAP-CA1 responses. Calibration: 0.5 mV, 5 ms. (D) Curve fitting of post LTP daily mTAP-CA1 putative population spike amplitude averages indicates population spike potentiation decays exponentially with a time constant (τ) of 9.6 days to decay 63.2% of maximal LTP.
Article Snippet: Averaged daily data were plotted with an
Techniques: